All Organoid Research Models

HOPX-Associated Molecular Programs Control Cardiomyocyte Cell States Underpinning Cardiac Structure and Function

[Developmental Cell] Deciphering the Regulatory Landscape: HOPX-Associated Molecular Programs Steering Cardiomyocyte Cell States in Support of Cardiac Structure and Function.

Cardiac/Heart Organoids

Dec 10, 2023

Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer

[Cancer Letters] Unraveling the Complexity of Pancreatobiliary Cancer: Comprehensive Single-Cell Transcriptome Profiling in Primary Tumors and Their Paired Organoids for In-Depth Molecular Insights.

Pancreatic Organoids

Dec 09, 2023

RAAS-Deficient Organoids Indicate Delayed Angiogenesis as a Possible Cause for Autosomal Recessive Renal Tubular Dysgenesis

[Nature Communication] Organoid technology in autosomal recessive renal tubular dysplasia (AR-RTD) disease.

Kidney Organoids

Dec 09, 2023

IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B

[Cellular and Molecular Gastroenterology and Hepatology] Unveiling Enhanced Facultative Stem Cell State Elicited by IGF2BP1/IMP1 Deletion: A Comprehensive Exploration of Regulatory Mechanisms Involvin...

Intestinal Organoids

Dec 09, 2023

CRX Haploinsufficiency Compromises Photoreceptor Precursor Translocation and Differentiation in Human Retinal Organoids

[Stem Cell Research & Therapy] TEffect of haploinsufficiency of the CRX gene on migration and differentiation of photoreceptor cell precursors in human retinal organoids.

Retinal Organoids

Dec 05, 2023

The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived Organoids

[Journal of Clinical Investigayion] Different sources of extracellular matrix (ECM) affect the proliferation rate of pancreatic cancer-like organs in mice and humans, but have no substantial effect on...

Pancreatic Organoids

Dec 05, 2023

Neural Cell Engraftment Therapy for Sporadic Creutzfeldt-Jakob Disease Restores Neuroelectrophysiological Parameters in a Cerebral Organoid Model

[Stem Cell Research & Therapy] To investigate the therapeutic efficacy of cell therapy for sporadic Creutzfeldt-Jakob disease (sCJD) based on a human cerebral organoid model.

Brain & Neural Organoids

Dec 05, 2023

Murine Trophoblast Organoids as a Model for Trophoblast Development and CRISPR-Cas9 Screening

[Developmental Cell] The first-time construction of murine trophoblast-like organoids derived from mouse trophoblast stem cells or placenta.

Murine Trophoblast Organoids

Dec 05, 2023

Stage-Specific Dynamic Reorganization of Genome Topology Shapes Transcriptional Neighborhoods in Developing Human Retinal Organoids

[Cell Reports] Based on human retina-like organs, the spatiotemporal dynamics of genomic structure and its relationship with gene expression patterns were elucidated by high-resolution Hi-C mapping, p...

Retinal Organoids

Dec 02, 2023

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