All Organoid Research Models

Integrative Genome-Scale Analyses Reveal Post-Transcriptional Signatures of Early Human Small Intestinal Development in a Directed Differentiation Organoid Model

[BMC Genomics] Discover the microRNA signatures driving the early development of human small intestine with a novel organoid-based multi-omic study.

Intestinal Organoids

Oct 26, 2023

Genetic Vulnerability to Crohn’s Disease Reveals a Spatially Resolved Epithelial Restitution Program

[Science Translational Medicine] Researchers use organoid models to unravel how a Crohn`s disease risk variant disrupts intestinal healing, shedding light on tissue repair mechanisms.

Intestinal Organoids

Oct 25, 2023

Distinct Effects of Fgf7 and Fgf10 on the Terminal Differentiation of Murine Bladder Urothelium Revealed Using an Organoid Culture System

[BMC Urology] Organoid models shed light on bladder cell differentiation and urinary tract disorder studies. Unique function of Fgf7 was identified, which acts via PPARγ .

Bladder Organoids

Oct 24, 2023

Eye Lens Organoids Made Simple: Characterization of a New Three-Dimensional Organoid Model for Lens Development and Pathology

[Cells] The research established a mouse lens-like organoid with optical properties and monitored the spatiotemporal expression of key lens genes Jag1, Pax6, Prox1, Hsf4, and Cryab through multi-omics...

Retinal Organoids

Oct 18, 2023

Mpox Virus Infection and Drug Treatment Modelled in Human Skin Organoids

[Nature Microbiology] Human skin organoids as a robust experimental model for studying MPXV infection, mapping virus-host interactions and testing therapeutics.

Skin Organoids

Oct 12, 2023

Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis through Restoring Gut Microbiota and Metabolites

[Gastroenterology] Intestinal organ reveals that X inhibits the occurrence of colorectal cancer by manipulating the gut microbiota and metabolism.

Intestinal Organoids

Sep 11, 2023

Establishment of a Large-Scale Patient-Derived High-Risk Colorectal Adenoma Organoid Biobank for High-Throughput and High-Content Drug Screening

[Science] Combining CRISPR and organoid technique unveiled key player in the gut`s hormone orchestra, ZNF800 emerges as a chief repressor in enteroendocrine cell differentiation.

Intestinal Organoids

Sep 04, 2023

Organoid Screening Reveals Epigenetic Vulnerabilities in Human Colorectal Cancer

[Nature Chemical Biology] Utilizing patient-derived colon and rectum organoids, a robust drug screening platform has been established, highlighting the practicality of multi-parameter validation in en...

Intestinal Organoids

Jun 18, 2023

β-Hydroxybutyrate Suppresses Colorectal Cancer

[Science] Combining CRISPR and organoid technique unveiled key player in the gut`s hormone orchestra, ZNF800 emerges as a chief repressor in enteroendocrine cell differentiation.

Intestinal Organoids

Apr 27, 2023

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