All Organoid Research Models

Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects

[Cell] Researchers have established a human multi-chambered cardiac organoid platform, using this platform to reveal the individual occurrence of signals and contraction propagation between the heart ...

Cardiac/Heart Organoids

Nov 28, 2023

Temporal Morphogen Gradient-Driven Neural Induction Shapes Single Expanded Neuroepithelium Brain Organoids with Enhanced Cortical Identity

[Nature Commuication] The induction of neural differentiation driven by temporal morphogen gradients results in the formation of single expanded neuroepithelium brain organoids, exhibiting an enhanced...

Brain & Neural Organoids

Nov 28, 2023

A Multicellular Liver Organoid Model for Investigating Hepatitis C Virus Infection and Non-Alcoholic Fatty Liver Disease Progression

[Hepatology] The study developed a new liver disease model by co-culturing hPSC-derived liver organoids and macrophages. This approach led to the transformation of macrophages into Kupffer-like cells ...

Liver Organoids

Nov 17, 2023

Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease

[The EMBO Journal] The study developed a human liver organoid model for MASLD, testing the effects of oleic acid, palmitic acid, and TGF-β1. Findings show all three induce inflammation, but only TGF-...

Liver Organoids

Nov 14, 2023

Human Skeletal Muscle Organoids Model Fetal Myogenesis and Sustain Uncommitted PAX7 Myogenic Progenitors

[eLife] The study demonstrates that transplanting progenitor cells from skeletal muscle organoids into adult mice can enhance muscle regeneration. By mimicking muscle development and assessing the imp...

Muscle Organoids

Nov 14, 2023

Incorporation of Human iPSC-Derived Stromal Cells Creates a Pancreatic Cancer Organoid with Heterogeneous Cancer-Associated Fibroblasts

[Cell Reports] The study created pancreatic ductal adenocarcinoma organoids from patient-derived cells and iPSC-derived stromal and endothelial cells, using an air-liquid interface to accurately repro...

Pancreatic Organoids

Nov 12, 2023

Development of Functional Resident Macrophages in Human Pluripotent Stem Cell-derived Colonic

[Cell Stem Cell] The human colon-like organ derived from pluripotent stem cells can generate pluripotent hematopoietic progenitor cells and resident macrophages in functional tissues.

November, 12, 2023

Nov 12, 2023

Personalized Drug Screening In Patient-Derived Organoids Of Biliary Tract Cancer And Its Clinical Application

[Cell Reports Medicine] New research in BTC reveals how organoids derived from patients` tumors can guide chemotherapy choices. Validated in patient responses, this method offers a precise tool for ta...

Biliary Tract Cancer Organoids

Nov 08, 2023

Hepatitis C Virus Infects And Perturbs Liver Stem Cells

[mBio] This research utilizes an adult stem cell-derived liver organoid system to elucidate the progression of late-stage liver disease caused by Hepatitis C virus (HCV) infection. By studying liver o...

Liver Organoids

Nov 08, 2023

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