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Research Highlights

Cross-Site Reproducibility of Human Cortical Organoids Reveals Consistent Cell Type Composition and Architecture
Human Cortical Organoids Display Uniform Architecture Despite Varied Site Conditions

Human Cortical Organoid

Aug 22, 2024
A Single-Cell Transcriptomic Census of Mammalian Olfactory Epithelium Aging
Organoid-Based Study Uncovers Cellular Dynamics in the Aging Olfactory Epithelium

Olfactory Epithelium Organoid

Aug 21, 2024
Small Molecule Valproic Acid Enhances Ventral Patterning of Human Neural Tube Organoids by Regulating Wnt and Shh Signalling
Valproic Acid-Treated Human Neural Tube Organoids Show Enhanced Ventral Patterning

Brain & Neural Organoids

Aug 20, 2024
CCKBR+ Cancer Cells Contribute to the Intratumor Heterogeneity of Gastric Cancer and Confer Sensitivity to FOXO Inhibition
AT9283-Mediated Suppression of Colorectal Cancer Progression via MKK3 Targeting in Organoids

Gastric Organoids

Aug 20, 2024
Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Targeting PYGB-Dependent Glycogenolysis in Organoids as a Strategy for Cholangiocarcinoma Treatment

Cholangiocarcinoma Organoid

Aug 20, 2024
NXPH4 Mediated by m5C Contributes to the Malignant Characteristics of Colorectal Cancer via Inhibiting HIF1A Degradation
The Impact of NXPH4 on HIF1A Degradation and Malignant Traits in Colorectal Cancer Organoids

Colorectal Cancer Organoid

Aug 20, 2024
Repurposed AT9283 Triggers Anti-tumoral Effects by Targeting MKK3 Oncogenic Functions in Colorectal Cancer
AT9283-Mediated Suppression of Colorectal Cancer Progression via MKK3 Targeting in Organoids

Colorectal Cancer Organoid

Aug 20, 2024
Epigenetic Alterations of TP53INP1 by EHMT2 Regulate the Cell Cycle in Gastric Cancer
Utilizing Organoids to Unveil the Proliferative Impact of EHMT2 Inhibition in Gastric Cancer

Gastric Organoids

Aug 19, 2024
Integrative Drug Screening and Multiomic Characterization of Patient-derived Bladder Cancer Organoids Reveal Novel Molecular Correlates of Gemcitabine Response
Integrating Organoid Technology with Multiomics to Enhance Precision Medicine in Bladder Cancer

Bladder Cancer Organoid

Aug 17, 2024

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