Intestinal Organoids Research, Colon Organoids

Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis

[Microbiome] Discovery of Targeting DVF-LRRC19 Interaction through Organoid Models as a Novel Therapeutic Strategy for Ulcerative Colitis (UC).

Intestinal Organoids

Jan 03, 2024

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice

[Developmental Cell] Senescent Intestinal Stem Cells Contribute to Cell-Intrinsic Origins of Inflammaging in Mice.

Intestinal Organoids

Dec 18, 2023

Butyrate Reduces Adherent-Invasive E. coli-Evoked Disruption of Epithelial Mitochondrial Morphology and Barrier Function: Involvement of Free Fatty Acid Receptor 3

[Gut Microbes] Mitigating Adherent-Invasive E. coli-Induced Disruption: Butyrate's Impact on Epithelial Mitochondrial Morphology and Barrier Function Involving Free Fatty Acid Receptor 3.

Intestinal Organoids

Dec 15, 2023

Development and Characterization of NILK-2301, a Novel CEACAM5xCD3 κλ Bispecific Antibody for Immunotherapy of CEACAM5-Expressing Cancers

[Journal Of Hematology & Oncology] Development and Characterization of NILK-2301: A Novel CEACAM5xCD3 κλ Bispecific Antibody for the Immunotherapy of Cancers Expressing CEACAM5.

Intestinal Organoids

Dec 12, 2023

IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3B

[Cellular and Molecular Gastroenterology and Hepatology] Unveiling Enhanced Facultative Stem Cell State Elicited by IGF2BP1/IMP1 Deletion: A Comprehensive Exploration of Regulatory Mechanisms Involvin...

Intestinal Organoids

Dec 09, 2023

Development of Functional Resident Macrophages in Human Pluripotent Stem Cell-derived Colonic

[Cell Stem Cell] The human colon-like organ derived from pluripotent stem cells can generate pluripotent hematopoietic progenitor cells and resident macrophages in functional tissues.

November, 12, 2023

Nov 12, 2023

Personalized Drug Screening In Patient-Derived Organoids Of Biliary Tract Cancer And Its Clinical Application

[Cell Reports Medicine] New research in BTC reveals how organoids derived from patients` tumors can guide chemotherapy choices. Validated in patient responses, this method offers a precise tool for ta...

Biliary Tract Cancer Organoids

Nov 08, 2023

Potential Application of Intestinal Organoids in Intestinal Diseases

[Stem Cell Reviews and Reports] This review discusses intestinal organoid culture techniques and their application in gastrointestinal disease research. It highlights the role of intestinal epithelial...

Intestinal Organoids

Nov 08, 2023

Unbiased Transcription Factor CRISPR Screen Identifies ZNF800 as Master Repressor of Enteroendocrine Differentiation

[Science] Combining CRISPR and organoid technique unveiled key player in the gut`s hormone orchestra, ZNF800 emerges as a chief repressor in enteroendocrine cell differentiation.

Intestinal Organoids

Oct 26, 2023